Immortalized avian cell lines and use thereof
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United States of America Patent
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Jul 15, 2014
Grant Date -
Sep 12, 2013
app pub date -
Feb 25, 2013
filing date -
May 12, 2009
priority date (Note) -
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Abstract
The present invention relates to specific immortalized avian cell lines expressing telomerase reverse transcriptase (TERT), and exhibiting distinct biologics production patterns. More particularly, the present invention relates to immortalized avian cell line capable of either amplifying Flaviviridae but not capable of amplifying Vaccinia virus strain Copenhagen (VV-COP) nor Modified Vaccinia virus Ankara (MVA), or capable of amplifying both Flaviviridae and Poxviridae. The invention further relates to the use of said immortalized avian cell lines and related methods for producing biologics, including viruses and proteins.
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