Method for increasing protein expression in cells
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United States of America Patent
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Jul 29, 2014
Grant Date -
Dec 15, 2011
app pub date -
Jan 19, 2010
filing date -
Jan 19, 2009
priority date (Note) -
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Abstract
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences.
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