Influenza A virus vaccines and inhibitors
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United States of America Patent
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Aug 5, 2014
Grant Date -
Feb 13, 2014
app pub date -
May 31, 2013
filing date -
Dec 2, 2005
priority date (Note) -
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Abstract
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
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