Template fixed beta-hairpin loop mimetics and their use in phage display

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United States of America Patent

PATENT NO 8796183
APP PUB NO 20110319291A1
SERIAL NO

13196712

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Abstract

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A method of screening for template-fixed β-hairpin mimetics and libraries including a plurality of these mimetics is provided. The template-fixed β-hairpin mimetics are of the following general formula:

description='In-line Formulae' end='lead'R1-Cys-Z-Cys-R2  Idescription='In-line Formulae' end='tail'

wherein the two cysteine residues are bridged by a disulfide bond, thereby forming a cyclic peptide; R1 and R2 are di- or tripeptide moieties of certain types, as defined herein; and Z is a chain of n amino acid residues with n being an integer from 4 to 20 and with each of these n amino acid residues being, independently, derived from any naturally occurring L-α-amino acid.

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Patent Owner(s)

Patent OwnerAddress
POLYPHOR LTDHEGENHEIMERMATTWEG 125 ALLSCHWIL 4123

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gombert, Frank Otto Huttingen, DE 19 178
Jung, Françoise Zürich, CH 7 55
Locurio, Sergio Küsnacht, CH 4 69
Ludin, Christian Aesch, CH 30 369
Obrecht, Daniel Blättwil, CN 82 589
Vrijbloed, Jan Wim Zürich, CH 18 200

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