Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preparation thereof
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United States of America Patent
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Aug 12, 2014
Grant Date -
Jan 24, 2013
app pub date -
Jul 16, 2012
filing date -
Sep 3, 2004
priority date (Note) -
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status (Latency Note)
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Abstract
Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07F:ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CO....
- C12P:FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESI....
- C08G:MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN B....
- B82Y:SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; ....
- C04B:LIME; MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREO....
- C08F:MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONL....
- C07C:ACYCLIC OR CARBOCYCLIC COMPOUNDS
- B22F:WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES F....
- H01F:MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF M....
- C07K:PEPTIDES
- C08L:COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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