CD40-L Inhibitory Peptides
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United States of America Patent
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Aug 12, 2014
Grant Date -
Mar 15, 2012
app pub date -
Jul 13, 2009
filing date -
Jul 11, 2008
priority date (Note) -
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Abstract
The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
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