Peptoids and methods for treating alzheimer's disease

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United States of America Patent

PATENT NO 8809275
APP PUB NO 20130102539A1
SERIAL NO

13656198

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Abstract

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Provided herein are peptoids capable of inhibiting or reversing amyloid β (Aβ) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at least two monomers with a side-chain having an arylalkyl group having the same chirality positioned such that the side-chains are on the same side of the peptoid. Also provided are methods of using the peptoids to inhibit or reverse aggregation of Aβ and methods of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD.

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Patent Owner(s)

  • BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;UNIVERSITY OF SOUTH CAROLINA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Moss, Melissa Columbia, US 6 14
Servoss, Shannon Fayetteville, US 4 3

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