Antibodies and vaccines for use in therapeutic and diagnostic methods for α-synuclein-related disorders

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United States of America Patent

PATENT NO 8809506
APP PUB NO 20110052498A1
SERIAL NO

12990226

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Abstract

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A vaccine for delaying an onset of or for treatment of an α-synuclein-related disorder in an individual comprises a therapeutically effective amount of isolated stabilized soluble α-synuclein oligomer having a lower formation rate to a non-soluble aggregated form than a non-stabilized oligomer of the α-synuclein. An antibody for delaying an onset of or for treatment of an α-synuclein-related disorder in an individual binds soluble α-synuclein. Methods for delaying an onset of for treatment or for prevention of an α-synuclein-related disorder employ the vaccine or antibody. Methods of detecting α-synuclein oligomers employ the antibody.

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Patent Owner(s)

Patent OwnerAddress
BIOARCTIC NEUROSCIENCE ABSTOCKHOLM SWE STOCKHOLM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bergström, Joakim Uppsala, SE 28 361
Gellerfors, Pär Lindingö, SE 13 158
Ingelsson, Martin Uppsala, SE 4 45
Lannfelt, Lars Stockholm, SE 25 433

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