Tandem facial amphiphiles
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United States of America Patent
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Aug 26, 2014
Grant Date -
May 9, 2013
app pub date -
Nov 5, 2012
filing date -
Nov 7, 2011
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Abstract
The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display favorable behavior with several membrane proteins. These amphiphiles can form relatively small micelles, and small changes in amphiphile chemical structures can result in large changes in their physical properties. The tandem facial amphiphiles can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
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