Compositions and methods for immunostimulatory RNA oligonucleotides

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United States of America Patent

PATENT NO 8815503
APP PUB NO 20090111765A1
SERIAL NO

12066906

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Abstract

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The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.

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Patent Owner(s)

Patent OwnerAddress
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN53113 BONN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hartmann, Gunther Bonn, DE 49 2112
Hornung, Veit Pullach, DE 14 163

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