Methods and compositions for detecting the activation state of multiple proteins in single cells

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United States of America Patent

PATENT NO 8815527
APP PUB NO 20130177970A1
SERIAL NO

13094737

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Abstract

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The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nolan, Garry P San Francisco, US 130 2098
Perez, Omar D San Francisco, US 37 767

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