Production of galactosylated glycoproteins in lower eukaryotes
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United States of America Patent
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Aug 26, 2014
Grant Date -
Mar 3, 2011
app pub date -
Jul 21, 2010
filing date -
Jun 28, 2000
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Abstract
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
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