Predicting toxicity of a compound over a range of concentrations
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United States of America Patent
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Aug 26, 2014
Grant Date -
Aug 30, 2012
app pub date -
Feb 22, 2012
filing date -
Feb 28, 2011
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Abstract
A method of predicting hepatotoxicity of a compound. The method includes imaging cells of hepatic origin positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the hepatotoxicity of the compound.
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