Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury

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United States of America Patent

PATENT NO 8828416
APP PUB NO 20050202059A1
SERIAL NO

10796397

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Abstract

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Medical devices, in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

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Patent Owner(s)

Patent OwnerAddress
WYETH5 GIRALDA FARMS MADISON NJ 07940

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Falotico, Robert Belle Mead, US 88 4588
Parry, Tom Jay Hellertown, US 9 231
Zhao, Jonathon Z Belle Mead, US 77 2452

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