Immunoglobulin molecules with improved characteristics
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United States of America Patent
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Sep 16, 2014
Grant Date -
Aug 2, 2012
app pub date -
Mar 27, 2012
filing date -
May 31, 2005
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Abstract
The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutations are also provided, that in combination, can be used to block FcRn function and thereby increase the clearance rates of other (endogenous or exogenous) IgGs, block placental transport of IgGs and have increased affinity/reduced pH dependence for FcRn binding.
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