Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane

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United States of America Patent

PATENT NO 8834924
SERIAL NO

13134467

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Abstract

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The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Tmax within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of Tmax.

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Patent Owner(s)

  • FOREST LABORATORIES HOLDINGS LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abramowitz, Wattanaporn West Windsor, US 19 149
Dedhiya, Mahendra G Pomona, US 68 547
Hauptmeier, Bernhard Gelnhausen, DE 27 79
Janjikhel, Rajiv South Setauket, US 8 140
Periclou, Antonia Jersey City, US 21 187
Rao, Niranjan Belle Mead, US 29 244
Seiller, Erhard Nidderau, DE 13 126
Yang, Yan Roslyn Heights, US 234 1390

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