2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors

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United States of America Patent

PATENT NO 8835435
APP PUB NO 20120053186A1
SERIAL NO

13015664

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Abstract

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Novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.

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AB SCIENCEPARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ciufolini, Marco Vancouver, CA 26 137
Giethlen, Bruno Altorf, FR 36 371
Moussy, Alain Paris, FR 75 376
Wermuth, Camille Strasbourg, FR 10 80

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