Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
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United States of America Patent
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Sep 16, 2014
Grant Date -
Sep 22, 2011
app pub date -
May 27, 2011
filing date -
Nov 7, 2002
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Abstract
(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for overactive bladder.
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