Calicheamicin derivative-carrier conjugates

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United States of America Patent

PATENT NO 8835611
SERIAL NO

13372172

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Abstract

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Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

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Patent Owner(s)

Patent OwnerAddress
WYETH HOLDINGS LLCFIVE GIRALDA FARMS MADISON NJ 07940

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Damle, Nitin Krishnaji Upper Saddle River, US 16 164
Dijoseph, John Francis Woodbridge, US 12 239
Jain, Neera New City, US 14 198
Kunz, Arthur New City, US 20 727
Merchant, Nishith Palisades Park, US 16 395
Moran, Justin Keith Valley Cottage, US 59 651
Popplewell, Andrew George Middlesex, GB 51 584
Robbins, Paul David Upper Nyack, US 8 164
Rubino, Joseph Thomas Towace, US 9 195
Ruppen, Mark Edward Garnerville, US 49 421
Simpson, John McLean Upper Nyack, US 6 144
Vidunas, Eugene Joseph Middletown, US 9 171

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