Process for manufacturing vaccines

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United States of America Patent

PATENT NO 8846049
APP PUB NO 20130004532A1
SERIAL NO

13457891

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Abstract

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The present application discloses an improved method for conducting saccharide—protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide or protein carrier involved, the quality of the conjugate may be improved by adding one of the reaction components slowly to the reaction mixture. Immunogenic compositions are further provided comprising the saccharide-protein conjugates made by the methods disclosed.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Biemans, Ralph Leon Rixensart, BE 45 623
Duvivier, Pierre Rixensart, BE 26 325

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