Crystallisation and purification of glycopyrronium bromide

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United States of America Patent

PATENT NO 8846954
APP PUB NO 20080227988A1
SERIAL NO

11817166

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Abstract

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A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favors the R,S and S,R diastereoisomers over the R,R, and S,S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallization steps. This method gives a product having a particle size of narrow distribution.

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Patent Owner(s)

Patent OwnerAddress
HEPTARES THERAPEUTICS LIMITEDCAMBRIDGE CB21 6DG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baxter, Andrew Douglas Cambridge, GB 71 368
Kleinebekel, Stefan Bielefeld, DE 2 16
Sinden, Kenneth Walter Essex, GB 2 13

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