Electron beam sculpting of tunneling junction for nanopore DNA sequencing
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United States of America Patent
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Oct 7, 2014
Grant Date -
Aug 2, 2012
app pub date -
Jan 27, 2012
filing date -
Jan 28, 2011
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Abstract
A nanodevice is provided that includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an electrode layer having a tunneling junction formed therein. A nanopore is formed through the membrane, and the nanopore is formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.
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