Methods and devices for hybridization and binding assays using thermophoresis
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United States of America Patent
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Oct 7, 2014
Grant Date -
Jan 10, 2008
app pub date -
Jun 7, 2007
filing date -
Oct 23, 2001
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Abstract
Methods for performing a hybridization assay between a target biomolecule and an array comprising a surface to which are attached biomolecular probes with different, known sequences, at discrete, known locations, the method comprising: providing a container holding a hybridization mixture comprising the target biomolecule and also holding the array; and creating a temperature gradient in the hybridization mixture oriented within the container such that at least a portion of the target biomolecule is driven onto the surface of the array.
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