Prostate stem cell antigen (PSCA) variants and subsequences thereof
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United States of America Patent
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Oct 7, 2014
Grant Date -
Mar 4, 2010
app pub date -
Sep 17, 2009
filing date -
May 30, 2003
priority date (Note) -
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Abstract
PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
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