Pharmaceutical compositions which inhibit FKBP52-mediated regulation of androgen receptor function and methods of using same

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United States of America Patent

PATENT NO 8859207
SERIAL NO

13395976

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Abstract

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Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Balsiger, Heather El Paso, US 1 2
Cox, Marc B El Paso, US 5 4
Iwai, Aki Toride, JP 3 3
Kim, Yeong Sang Gaithersburg, US 7 72
Neckers, Jane B Bethesda, US 7 5
Neckers, Leonard M Bethesda, US 15 14
Ning, Yangmin Silver Spring, US 3 3
Tonos, de Leon Johanny Frederick, US 2 2

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