Protofibril-binding antibodies and their use in thereapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies

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United States of America Patent

PATENT NO 8859501
APP PUB NO 20130309251A1
SERIAL NO

13957239

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Abstract

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Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity Determining Region (CDR) sequences. Compositions comprise such an antibody or fragment and methods of detecting α-synuclein protofibrils use such an antibody or fragment. In further embodiments, methods of preventing, delaying onset of or treating a neurodegenerative disorder with α-synuclein pathology comprise administering such an antibody or fragment, and such an antibody or fragment is used in the manufacture of a pharmaceutical composition for treatment of a neurodegenerative disorder with α-synuclein pathology. Such an antibody or fragment is used in the diagnosis or monitoring of the development of a neurodegenerative disorder with α-synuclein pathology, and in methods for reducing or inhibiting α-synuclein aggregation by administration of such an antibody or fragment.

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Patent Owner(s)

  • BIOARCTIC NEUROSCIENCE AB

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ekberg, Monica Stockholm, SE 4 57
Holmquist, Mats Sollentuna, SE 11 94
Kasrayan, Alex Stockholm, SE 4 57
Lannfelt, Lars Stockholm, SE 25 415
Nordström, Eva Rönninge, SE 6 57
Screpanti, Sundquist Valentina Spånga, SE 3 29

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