Methods and compositions for the treatment of immune disorders

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United States of America Patent

PATENT NO 8871205
SERIAL NO

13511933

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a method of treating an immune-related disorder in a subject, comprising administering to the subject an effective amount of an inhibitor of plexin-A4 activity, which results in reducing the plexin-A4 activity in the subject, and thereby treating the immune-related disorder. Inhibitors of plexin-A4 activity include, for example, plexin-A4 antibodies and plexin-A4 fusion proteins. The present invention further provides a method of treating an immune-related disorder in a subject, comprising administering to the subject an effective amount of an inhibitor of semaphorin-3A (Sema3A) activity, which results in reducing the Sema3A activity in the subject, thereby treating the immune-related disorder. Inhibitors of Sema3A activity include, for example, Sema3A antibodies and Sema3A fusion proteins.

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Patent Owner(s)

  • THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ting, Jenny P-Y Chapel Hill, US 13 24
Wen, Haitao Carrboro, US 9 15

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