Neutralizing anti-influenza A virus antibodies and uses thereof
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United States of America Patent
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Oct 28, 2014
Grant Date -
Nov 10, 2011
app pub date -
Jul 18, 2011
filing date -
Jul 25, 2008
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Abstract
The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to an epitope in the stem region of an influenza A hemagglutinin trimer and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
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