HSV-1 and HSV-2 vaccines and methods of use thereof

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United States of America Patent

PATENT NO 8871223
APP PUB NO 20110177125A1
SERIAL NO

12440223

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Abstract

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This invention provides methods of vaccinating a subject against a Herpes Simplex Virus (HSV) infection and disorders and symptoms associated with same, and impeding, inhibiting, reducing the incidence of, and suppressing HSV infection, neuronal viral spread, formation of zosteriform lesions, herpetic ocular disease, herpes-mediated encephalitis, and genital ulcer disease in a subject, comprising the step of contacting the subject with a mutant strain of the HSV, containing an inactivating mutation in a gene encoding a gE, gI, Us9, or other proteins.

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Patent Owner(s)

  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Friedman, Harvey Merion, US 15 95
Wang, Fushan Broomall, US 4 13
Zumbrun, Elizabeth E Middletown, US 3 25

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