Method for inducing tissue growth, differentiation and/or regeneration by delivering a GDF-5 related precursor protein
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United States of America Patent
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Oct 28, 2014
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Dec 20, 2012
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Jul 18, 2006
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Abstract
This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. The compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The compositions can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.
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