Pharmaceutical combination for the treatment and/or chemosensibilization of refractory tumors to anticancer drugs

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United States of America Patent

PATENT NO 8871725
APP PUB NO 20090130228A1
SERIAL NO

12280629

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Abstract

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This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

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Patent Owner(s)

Patent OwnerAddress
BIOREC S ACERRITO 532 OFICINA 802 MONTEVIDEO C P 11 000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alonso, Daniel Fernando Buenos Aires, AR 6 29
Castro, Boris Ernesto Acevedo Ciudad De La Habana, CU 7 22
Duque, Jorge Fernández de Cossio Dorta Ciudad De La Habana, CU 1 3
Gómez, Yassel Ramos Ciudad De La Habana, CU 1 3
Gomez, Daniel Eduardo Buenos Aires, AR 5 29
López, Luis Javier González Ciudad De La Habana, CU 2 3
Núñez, Lázaro Hiram Betancourt Ciudad De La Habana, CU 1 3
Negrin, Yasser Perera La Habana, CU 2 3
Pérez, Vladimir Besada Ciudad De La Habana, CU 1 3
Puente, Aniel Sánchez Ciudad de La Habana, CU 1 3
Rodriguez, Silvio Ernesto Perea Ciudad De La Habana, CU 4 6
Serra, Lila Rosa Castellanos Ciudad de La Habana, CU 2 3
Ulloa, Arielis Rodriguez La Habana, CU 1 3
Valdés, Jeovanis Gil Ciudad De La Habana, CU 1 3

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