Modification of CXCR4 using engineered zinc finger proteins

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United States of America Patent

PATENT NO 8871905
APP PUB NO 20100291048A1
SERIAL NO

12661539

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.

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Patent Owner(s)

  • SANGAMO THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Holmes, Michael C Oakland, US 87 3596
Miller, Jeffrey C San Leandro, US 103 3609
Wang, Jianbin San Ramon, US 53 1128

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