Methods of preparing tissues for xenotransplantation using α-galactosidases

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United States of America Patent

PATENT NO 8883478
SERIAL NO

12709070

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This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of α3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.

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DRUG ROYALTY III LP 2FIRST CANADIAN PLACE 100 KING ST WEST SUITE 7250 P O BOX 62 C/O DRI CAPITAL INC TORONTO M5X 1B1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clausen, Henrik Holte, DK 83 1003
Liu, Qiyong Peter Newton, US 38 229

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