NOTCH inhibition in the treatment and prevention of a metabolic disease or disorder and cardiovascular complications thereof

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United States of America Patent

PATENT NO 8889131
SERIAL NO

13461365

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods for determining whether a patient is at increased risk for developing these conditions by determining the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analysis.

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Patent Owner(s)

  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aikawa, Elena Chestnut, US 15 55
Aikawa, Masanori Chestnut Hill, US 23 120
Fukuda, Daiju Brookline, US 3 38
Miyazaki, Tetsuro Brookline, US 45 808

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