Flavivirus host-range mutations and uses thereof

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United States of America Patent

PATENT NO 8889148
SERIAL NO

13173895

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Abstract

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Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.

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  • RESEARCH DEVELOPMENT FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, Dennis T Raleigh, US 12 129
Hernandez, Raquel Raleigh, US 5 15

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