System and method useful for sarcomere imaging via objective-based microscopy

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United States of America Patent

PATENT NO 8897858
SERIAL NO

13305390

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Abstract

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Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Delp, Scott L Stanford, US 24 2528
Llewellyn, Michael E Palo Alto, US 8 269
Sanchez, Gabriel Nestor Stanford, US 5 45
Schnitzer, Mark J Palo Alto, US 26 930

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