Methods and compositions related to clot-binding compounds
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United States of America Patent
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Dec 16, 2014
Grant Date -
Jul 7, 2011
app pub date -
Dec 20, 2010
filing date -
Dec 18, 2009
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Abstract
Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors. The modified clot-binding compound can enhance the clotting in tumors compared to its unmodified derivative. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
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