Template-fixed peptidomimetics

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United States of America Patent

PATENT NO 8921325
SERIAL NO

13764099

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Abstract

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The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.

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Patent Owner(s)

Patent OwnerAddress
POLYPHOR LTDHEGENHEIMERMATTWEG 125 ALLSCHWIL 4123

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Demarco, Steven J Diegten, CH 22 174
Gombert, Frank Binningen, CH 29 241
Henze, Heiko Zurich, CH 18 132
Ludin, Christian Oberwil, CH 30 369
Moehle, Kerstin Wettswil, CH 19 135
Mukherjee, Reshmi Pasadena, US 13 101
Obrecht, Daniel Baettwil, CH 82 589
Robinson, John-Anthony Wermatswil, CH 7 32
Romagnoli, Barbara Binningen, CH 23 211
Vrijbloed, Jan Wim Moehlin, CH 18 200

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