Treatment of preterm labor with toll-like receptor 9 antagonists
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United States of America Patent
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Jan 13, 2015
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Sep 24, 2009
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Sep 24, 2008
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Abstract
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. The compositions and methods of the present invention enhance gestation and therefore improve neonatal morbidity and mortality.
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