Methods and compositions comprising sequential administration opioid receptor agonists
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United States of America Patent
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Jan 13, 2015
Grant Date -
Dec 6, 2012
app pub date -
May 31, 2012
filing date -
May 31, 2011
priority date (Note) -
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Abstract
Methods and compositions for the alleviation of pain in a patient. The methods and compositions sequentially administer a therapeutically effective amount of first compound having opioid receptor agonist activity, followed by a therapeutic effective amount of a second or subsequent compound(s) having opioid receptor agonist activity, one or more non-opioid analgesic compounds or one or more hybrid opioid compounds, or mixtures thereof. The methods and compositions effectively alleviate pain with a lower incidence of opioid-induced side effects.
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