Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents

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United States of America Patent

PATENT NO 8936635
APP PUB NO 20120245677A1
SERIAL NO

13426948

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Abstract

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The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.

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Patent Owner(s)

Patent OwnerAddress
PALMETTO PHARMACEUTICALS LLC211 KING STREET SUITE 105 CHARLESTON SC 29401

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kaesemeyer, Wayne H Chapel Hill, US 15 88

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