Hydrogel tissue adhesive having reduced degradation time
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United States of America Patent
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Feb 10, 2015
Grant Date -
Feb 9, 2012
app pub date -
Apr 9, 2010
filing date -
Apr 9, 2009
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Abstract
A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm polyether amine in the presence of an oligomer additive, which promotes the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.
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