Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Feb 24, 2015
Grant Date -
Feb 14, 2013
app pub date -
Feb 14, 2011
filing date -
Feb 12, 2010
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully