Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
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United States of America Patent
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Feb 24, 2015
Grant Date -
Oct 6, 2011
app pub date -
Dec 10, 2009
filing date -
Dec 12, 2008
priority date (Note) -
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Abstract
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
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