Cell line, system and method for optical control of secondary messengers

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United States of America Patent

PATENT NO 8962589
APP PUB NO 20130331441A1
SERIAL NO

13850426

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Abstract

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A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, Beta2)}. The light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Airan, Raag D Menlo Park, US 16 628
Deisseroth, Karl Stanford, US 135 6299

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