-functionalization of morphine and tropane alkaloids

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United States of America Patent

PATENT NO 8962841
SERIAL NO

13178623

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Abstract

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The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.

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BROCK UNIVERSITY500 GLENRIDGE AVENUE ST CATHARINES L2S 3A1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carroll, Robert James Herts, GB 5 69
Endoma-Arias, Mary Ann Quezon, PH 7 20
Hudlicky, Tomas St. Catharines, CA 33 176
Leisch, Hannes Unterach am Attersee, AT 6 59
Machara, Ales Brevnov, CZ 10 27
Werner, Lukas Kadan, CZ 12 39

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