Hydroxycholesterol immunoassay

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United States of America Patent

PATENT NO 8969525
SERIAL NO

12927206

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Abstract

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Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective.

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Patent Owner(s)

Patent OwnerAddress
ENZO LIFE SCIENCES INC C/O ENZO BIOCHEM INC10 EXECUTIVE BLVD FARMINGADALE NY 11735

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, Jeffrey Kroll Fort Washington, US 15 132
Donegan, James J Long Beach, US 138 1032
Mullenix, Michael C Saline, US 9 52
Patton, Wayne Forrest Dix Hills, US 40 210
Zipkin, Robert Elliot Wynnewood, US 15 110

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