Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing
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United States of America Patent
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Mar 10, 2015
Grant Date -
Nov 6, 2014
app pub date -
May 29, 2013
filing date -
May 6, 2013
priority date (Note) -
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Abstract
A technique is provided for base recognition in an integrated device is provided. A target molecule is driven into a nanopore of the integrated device. The integrated device includes a nanowire separated into a left nanowire part and a right nanowire part to form a nanogap in between, a source pad connected to the right nanowire part, a drain pad connected to the left nanowire part, and the nanopore. The source pad, the drain pad, the right nanowire part, the left nanowire part, and the nanogap together form a transistor. The nanogap is part of the nanopore. A transistor current is measured while a single base of the target molecule is in the nanogap of the nanopore, and the single base affects the transistor current. An identity of the single base is determined according to a change in the transistor current.
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