G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker
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United States of America Patent
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Mar 17, 2015
Grant Date -
Jul 18, 2013
app pub date -
Mar 13, 2013
filing date -
Jul 14, 2009
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Abstract
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments present in a biological sample of the subject. Because cancer can be detected at an early stage, therapeutic targeting may be initiated before cancer reaches late stage (e.g., before the development of overt symptoms). A method for treating early stage cancer in a subject comprises administering to the subject an effective amount of a GASP-1 inhibitor to inhibit the progression of early stage cancer to late stage cancer. A Competitive ELISA capable of detecting GASP-1 peptide fragments at a concentration of less than 1 ng/ml was developed.
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