Hair follicle precursor production by co-culturing mammalian dermal papilla cells and keratinocytes
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United States of America Patent
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Mar 17, 2015
Grant Date -
Aug 6, 2009
app pub date -
Mar 15, 2007
filing date -
Mar 17, 2006
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Abstract
This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.
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